Cost Saving Opportunities in NSCLC Therapy by Optimized Diagnostics

Cost Saving Opportunities in NSCLC Therapy by Optimized Diagnostics

With an incidence of 68 new cases per 100,000 people per year, an estimated total number of up to 350,000 new non-small-cell lung cancer (NSCLC) cases are diagnosed each year in the European Union. Up to 10% of NSCLC patients are eligible for therapy with novel ALK (anaplastic lymphoma kinase) inhibitors, as they have been diagnosed with a mutation in the gene coding for ALK. The ALK inhibitor ...

Foot-in-wallet disease: tripped up by "cost-saving" reductions?

In the U.S., podiatric medical services are considered to be optional under Medicaid statutes, with an underlying assumption that these services are elective and can be performed by other providers. Itmay have been easily anticipated, therefore, that podiatric services were often included in line-item cuts in a number of state budgets under the recent period of economic austerity. Given this, t...

Cooperative vehicle routing problem: an opportunity for cost saving

In this paper, a novel methodology is proposed to solve a cooperative multi-depot vehicle routing problem. We establish a mathematical model for multi-owner VRP in which each owner (i.e. player) manages single or multiple depots. The basic idea consists of offering an option that owners cooperatively manage the VRP to save their costs. We present cooperative game theory techniques for cost savi...

Identifying Real Cost Saving in Lean Manufacturing

Sub-process Discovery: Opportunities for Process Diagnostics

Most business processes in real life are not strictly ruled by the information systems that support them. This behavior is reflected in the traces stored by information systems. It is useful to diagnose in early stages of business process analysis. Process diagnostics is part of the process mining and it encompasses process performance analysis, anomaly detection, and inspection of interesting ...